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Expanding HOPE Liver

NCT07778459 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2026-08-21

No results posted yet for this study

Summary

This is a prospective, multicenter clinical study. The objective is to determine whether a liver transplant from a deceased donor with HIV is associated with an increased risk of opportunistic infection and cancer. Adults with Human Immunodeficiency Virus (HIV) in need of a liver or simultaneous liver-kidney (SLK) transplant who meet study-specified criteria will be offered enrollment in the study. The analytic plan includes an observational cohort of liver and SLK transplant recipients from prior HOPE in Action studies.

Conditions

Sponsors & Collaborators

  • National Institute of Allergy and Infectious Diseases (NIAID)

    lead NIH

Principal Investigators

  • Christine Durand, MD · Johns Hopkins Hospital: Transplantation

  • Dorry Segev, MD, PhD · New York University Langone Health: Transplantation

  • Aaron Tobian, MD, PhD · Johns Hopkins Hospital: Transplantation

  • James P Hamilton, MD · Johns Hopkins Hospital: Transplantation

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-10-15
Primary Completion
2030-08-31
Completion
2030-08-31

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07778459 on ClinicalTrials.gov