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Epidemiology and Pathogenesis of HIV-Associated Pulmonary Hypertension

NCT00845013 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 365

Last updated 2021-11-10

No results posted yet for this study

Summary

The purpose of this study is to describe the epidemiology of pulmonary hypertension in individuals with HIV infection and to investigate its pathogenesis. We propose to conduct a prospective observational cohort study to determine the association between highly active antiretroviral therapy (HAART) and viral suppression in HIV-infected patients who have been identified to have pre-clinical pulmonary hypertension (Aim 1). In addition, we will investigate the mechanistic role of the HIV-1 Nef protein and HHV-8 infection in the development and progression of pulmonary hypertension in individuals with HIV (Aim 2). We will also investigate endothelial function in HIV-infected patients with pulmonary hypertension (Aim 3).

Conditions

  • HIV Infection
  • Pulmonary Hypertension
  • Endothelial Function
  • HIV Infections

Sponsors & Collaborators

Principal Investigators

  • Priscilla Hsue, MD · University of California, San Francisco

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2007-11-30
Primary Completion
2021-01-31
Completion
2021-01-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00845013 on ClinicalTrials.gov