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Zonulin Levels in Varicocele Patients

NCT07748104 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 119

Last updated 2026-08-05

No results posted yet for this study

Summary

This prospective cross-sectional observational study was designed to evaluate serum and seminal plasma zonulin levels in infertile men with clinically diagnosed varicocele and compare them with those in infertile men without varicocele. The study also aimed to investigate the association between zonulin concentrations and conventional semen parameters.

A total of 119 men evaluated for infertility between December 2022 and May 2023 were included. Participants were classified into two groups according to the presence or absence of clinically diagnosed varicocele. Serum and seminal plasma zonulin concentrations were measured using enzyme-linked immunosorbent assay (ELISA). Conventional semen parameters, including semen volume, sperm concentration, total sperm count, progressive motility, total motility, and normal sperm morphology, were evaluated and compared between the study groups.

Conditions

  • Varicocele
  • Male Infertility
  • Zonulin

Sponsors & Collaborators

  • Samsun University

    collaborator OTHER

  • Ondokuz Mayıs University

    collaborator OTHER

  • Süleyman Tümer Çalışkan

    lead OTHER

Principal Investigators

  • Süleyman T Çalışkan · Gazi State Hospital

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-12-01
Primary Completion
2023-05-31
Completion
2023-05-31

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07748104 on ClinicalTrials.gov