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Assessing Treatment With High-phenolic EVOO Supplements for Neurovascular Activity

NCT07741773 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-08-03

No results posted yet for this study

Summary

The goal of this clinical trial is to determine whether the extra-virgin olive oil (EVOO) phenolic dietary supplement can improve memory function and modulate biomarkers among individuals with mild cognitive impairment (MCI). The main questions it aims to answer are:

* Does dietary supplementation with EVOO phenolics improve cognitive function?
* What would be the effect of the EVOO dietary supplement on other MCI-related biomarkers, including vascular function and biological pathways?

Researchers will compare the EVOO dietary supplements with a placebo (a look-alike substance that contains no EVOO phenolics)

Participants will:

* Take EVOO dietary supplements or a placebo daily for 6 months
* Visit the study site during the 6-month study for screening and testing.

Conditions

  • Mild Cognitive Impairment (MCI)

Interventions

DIETARY_SUPPLEMENT

EVOO-phenolics dietary supplement

EVOO phenolic dietary supplement which is standardized to contain10 mg of EVOO total phenolics

DIETARY_SUPPLEMENT

Placebo

Placebo

Sponsors & Collaborators

  • Augusta University

    lead OTHER

Principal Investigators

  • Amal Kaddoumi, PhD · Augusta University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-09-01
Primary Completion
2028-08-31
Completion
2028-08-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07741773 on ClinicalTrials.gov