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Dose-response Effects of Dietary Nitrate on Running Time-to-exhaustion and Neuromuscular Fatigue: a Randomized Crossover Exploratory Pilot Study

NCT07735455 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 9

Last updated 2026-07-30

No results posted yet for this study

Summary

Background: Dietary nitrate is a natural compound found in vegetables such as beetroot and leafy greens. Previous research suggests that consuming nitrate before exercise may improve endurance and physical performance. However, it is still unclear whether higher doses provide greater benefits, particularly in recreationally trained individuals.

Purpose: This study aimed to investigate whether different doses of dietary nitrate taken before exercise influence endurance performance and muscle fatigue during a running test in recreationally trained men.

Methods: This randomized, double-blind, placebo-controlled crossover pilot study compared the effects of a placebo and three different doses of dietary nitrate consumed before exercise. On separate occasions, participants completed the same treadmill running test to exhaustion after ingesting the assigned supplement. Measures of muscle performance, blood lactate concentration, and perceived exertion were collected before and after exercise to evaluate the effects of dietary nitrate supplementation.

Conditions

  • Health Adult Subjects

Interventions

DIETARY_SUPPLEMENT

Dietary Nitrate

Participants received a single acute dose of dietary nitrate before exercise. Three doses were evaluated (4.8 mmol, 8.1 mmol, and 11.3 mmol), administered approximately 2.5 hours before the treadmill running test.

OTHER

Placebo

Participants received a nitrate-depleted placebo beverage approximately 2.5 hours before the treadmill running test.

Sponsors & Collaborators

  • Universidad Autonoma de Madrid

    lead OTHER

Principal Investigators

  • Helios Pareja Galeano · Universidad Autonoma de Madrid

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-10-01
Primary Completion
2025-09-30
Completion
2025-09-30

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07735455 on ClinicalTrials.gov