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Nitrate Formulations and Exercise Performance

NCT06531070 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2025-03-27

No results posted yet for this study

Summary

this study compares the acute effects of Nitrate and Nitrate plus citrulline supplementation on physical performance in recreationally trained males and females. This is a cross-over within-participant comparison design concluding three arms (i) 600 mg of Nitrate (N), ii) 600 mg Nitrate and Citrulline (NC) and (iii) Placebo (PL).

Conditions N, NC and PL will be tested one week apart, considering a minimum washout period of 72 hours.

Dependent variables:

* Number of completed repetitions to failure in squat using 75% of 1RM.
* Ventilatory thresholds (VT1) and (VT2) and Vo2 max from a progressive to exhaustion running test (PGT)
* Lactate post (within 1 min of having completed the PGT)
* Rating of perceived exertion (RPE) by the Borg 6-to-20-point scale recorded every 2 min and at the end of the PGT.
* Heart rate associated with VT1, VT2, and Vo2max - Heart rate maximum.
* Maximal aerobic speed (MAS): calculated from the average speed of the last 2 minutes of the PGT.
* time limit test at MAS (conducted after 15 min of having completed the PGT)

Conditions

  • Nitrate
  • Nitrate/Citrulline
  • Placebo

Interventions

DIETARY_SUPPLEMENT

Nitrate

A four-day supplementation period, separated by one week including a 3-day washout period between conditions will be applied before conducting strength and endurance assessments Days 1 to 3 the randomly assigned supplement (N, NC, or PLA) will be ingested 2 hr before a standard low-volume training session including 3 sets of 8 to 10 reps of squat and deadlift using a very light load (e.g., own body mass) and flexibility exercises following by 5 min of running at self-paced intensity rated as light (12) with the rating of perceived exertion Borg Scale. Day 4: the assigned supplement will be ingested 2.5 h before the assessments Assessment of strength and endurance will be conducted

Sponsors & Collaborators

  • Crown Sport Nutrition

    collaborator INDUSTRY

  • University of Greenwich

    lead OTHER

Principal Investigators

  • Fernando Naclerio · University of Greenwich

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-08-01
Primary Completion
2024-10-15
Completion
2024-12-15

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06531070 on ClinicalTrials.gov