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Cost-Effectiveness of Inhaled Sedation Versus Intravenous Propofol in Mechanically Ventilated Critically Ill Adults

NCT07734350 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 400

Last updated 2026-07-29

No results posted yet for this study

Summary

The goal of this observational study is to learn whether inhaled sedation is a cost-effective alternative to intravenous propofol in mechanically ventilated critically ill adults admitted to the intensive care unit. The main questions it aims to answer are:

* Does inhaled sedation reduce the total cost of care compared with intravenous propofol?
* Does inhaled sedation reduce the duration of mechanical ventilation and ICU length of stay?
* Are adverse events different between patients receiving inhaled sedation and those receiving intravenous propofol?

Researchers will compare patients who received inhaled sedation with patients who received intravenous propofol to see if inhaled sedation improves clinical outcomes and reduces overall costs.

Participants will:

* Be identified through review of electronic medical records
* Be included if they are adults who received mechanical ventilation and were sedated with inhaled sedation or intravenous propofol
* Contribute data on total costs of care, duration of mechanical ventilation, ICU length of stay, and adverse event

Conditions

  • Critical Illness
  • Mechanical Ventilation
  • Respiratory Insufficiency

Interventions

DRUG

Isoflurane

Isoflurane administered as inhaled sedation through an anesthetic-conserving device in mechanically ventilated critically ill adult patients in the intensive care unit.

DRUG

Propofol (Astra-Zeneca)

Propofol administered as continuous intravenous sedation in mechanically ventilated critically ill adult patients in the intensive care unit.

Sponsors & Collaborators

  • Hospital H+ Queretaro

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-07-29
Primary Completion
2026-09-30
Completion
2026-10-31
FDA Drug
Yes

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07734350 on ClinicalTrials.gov