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Inhalational Sedation and Mechanical Power

NCT05559970 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2026-05-07

No results posted yet for this study

Summary

Analgosedation is usually given to critically ill patients admitted in ICU. Fentanyl is the most common agent used for this purpose. For sedative agent, midazolam and propofol are commonly administered. However, too much sedation is apparently associated with increased duration of mechanical ventilation, prolonged ICU stay, and increased mortality.

In mechanically ventilated patients, mechanical power is the respiratory mechanic that can predict clinical outcomes including mortality in both ARDS and non-ARDS patients. Previous study demonstrated that sedating mechanically ventilated patients with propofol could decreased mechanical power. This was possibly associated with improved clinical outcomes in these patients.

At present, there is no clinical study investigating effects of inhalation sedation on mechanical power and clinical outcomes in mechanically ventilated patients.

Conditions

  • Mechanical Ventilation
  • Sedation
  • Mechanical Power
  • Lung Injury
  • ICU

Interventions

DRUG

Inhalational sedation

Inhalational sedation with isoflurane for 12 hours

DRUG

Convention sedation

Conventional sedation receiving analgosedation with fentanyl

Sponsors & Collaborators

  • Mahidol University

    lead OTHER

Principal Investigators

  • Annop Piriyapatsom, MD · Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-11-15
Primary Completion
2023-09-27
Completion
2024-04-30

Countries

  • Thailand

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05559970 on ClinicalTrials.gov