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Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Adults With Newly Diagnosed Hypertension

NCT07728630 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2026-07-27

No results posted yet for this study

Summary

Hypertension is associated with endothelial dysfunction, an early event in the development of cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation and vascular injury; however, their relationship with blood pressure and microvascular endothelial function in untreated hypertension remains insufficiently understood. This observational case-control study aims to compare circulating EEV concentrations between normotensive adults and adults with newly diagnosed, untreated primary hypertension. In addition, the study will investigate the associations between EEV levels, blood pressure, microvascular endothelial function assessed by laser Doppler flowmetry, and established circulating biomarkers of endothelial activation. The findings may improve understanding of the role of EEVs in early hypertension and support their potential use as non-invasive biomarkers of endothelial dysfunction and cardiovascular risk.

Conditions

Sponsors & Collaborators

  • Osijek University Hospital

    collaborator OTHER

  • Josip Juraj Strossmayer University of Osijek

    lead OTHER

Principal Investigators

  • Ana Stupin, MD, PhD · Faculty of Medicine Osijek, Josip Juraj Strossmayer of Osijek

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-05-01
Primary Completion
2029-04-30
Completion
2029-09-30

Countries

  • Croatia

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07728630 on ClinicalTrials.gov