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Placental Progesterone Membrane Receptors in Fetal Growth Restriction

NCT07701837 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 110

Last updated 2026-08-07

No results posted yet for this study

Summary

This prospective observational case-control study aims to compare placental expression levels of progesterone membrane receptors, including PGRMC1, PGRMC2, and PAQR family receptors, among pregnancies affected by impaired fetal growth and appropriately grown control pregnancies. Pregnancies with suspected impaired fetal growth were phenotypically classified before biomarker analyses according to the contemporary Delphi consensus and ISUOG diagnostic criteria into fetal growth restriction (FGR) and small for gestational age (SGA). Placental tissue samples obtained at delivery were analyzed using quantitative real-time polymerase chain reaction (qRT-PCR). The final study cohort comprised 110 singleton pregnancies, including 48 FGR, 29 SGA, and 33 appropriately grown controls. The study also evaluated the association between progesterone membrane receptor expression and adverse perinatal outcomes.

Conditions

  • Fetal Growth Restriction
  • Placenta
  • Progesterone Membrane Receptor
  • PGRMC1
  • PGRMC2
  • Placental Dysfunction
  • Pregnancy

Sponsors & Collaborators

  • Samsun University

    lead OTHER

Principal Investigators

  • Canan Soyer Çalışkan, MD, Associate Professor · Samsun University, Samsun Education and Research Hospital, Samsun, Turkey

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-08-01
Primary Completion
2026-07-20
Completion
2026-07-20

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07701837 on ClinicalTrials.gov