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Alterations in the Plasma Proteome of Early-Onset Severe Preeclampsia

NCT00719654 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 316

Last updated 2018-05-18

No results posted yet for this study

Summary

The hypothesis of this study is that many plasma proteins are altered in concentration and structure in preeclampsia and the elucidation of these alterations will add to the poorly understood pathophysiology of preeclampsia. In this study we will compare the maternal plasma proteomes of early-onset severe preeclampsia versus healthy controls, compare protein expression and quantification of the maternal plasma proteome at the time of diagnosis of EOS-preeclampsia to the plasma proteome of the same affected subject at 48 hours post delivery and we will verify the placental expression of differentially expressed or post-translationally modified proteins found in the plasma of women with EOS-preeclampsia.

Conditions

Sponsors & Collaborators

  • National Center for Research Resources (NCRR)

    collaborator NIH

  • Medical University of South Carolina

    lead OTHER

Principal Investigators

  • Christopher Robinson, MD · Medical University of South Carolina

  • Donna Johnson · Medical University of South Carolina, Obstetrics-Gynecology

Eligibility

Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2007-08-31
Primary Completion
2012-04-09
Completion
2012-04-09

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00719654 on ClinicalTrials.gov