Placental Growth Factor Assessment of Women With Suspected Pre-eclampsia

Summary

The primary aim is to establish the effectiveness of plasma PlGF measurement in reducing maternal morbidity (with assessment of perinatal safety in parallel) in women presenting with suspected pre-eclampsia prior to 37 weeks' gestation.

The long term aim is to demonstrate that knowledge of PlGF measurement enables appropriate stratification of the antenatal management of women presenting with suspected pre-eclampsia, such that those at highest risk receive greater surveillance with a decrease in maternal adverse outcomes, and those at lower risk can be managed without unnecessary admission and other interventions, such that the results would influence international clinical practice in antenatal patient healthcare

Conditions

• Pre-eclampsia
• Pregnancy, High Risk
• Pregnancy Complications

Interventions

OTHER

Maternal plasma PlGF quantification

A point of care test performed on maternal plasma, to quantify the level of the protein PlGF (placental growth factor) in the serum of the pregnant woman with suspected pre eclampsia to help the clinician in stratifying the level of further care for her in her pregnancy

Sponsors & Collaborators

• National Maternity Hospital, Ireland

  collaborator OTHER

• Rotunda Maternity Hospital, Dublin

  collaborator UNKNOWN

• Coombe Women and Infants University Hospital

  collaborator OTHER

• University College Hospital Galway

  collaborator OTHER

• Royal Jubilee Maternity Hospital, Belfast

  collaborator UNKNOWN

• Cork University Maternity Hospital

  collaborator OTHER

• Univerisy Maternity Hospital, Limerick

  collaborator UNKNOWN

• University College Cork

  collaborator OTHER

• Irish Centre for Fetal and Neonatal Translational Research

  lead OTHER

Principal Investigators

• Louise C Kenny, PhD, MD · Irish Centre for Fetal and Neonatal Translational Research

Study Design

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-06-29

Primary Completion

2019-04-26

Completion

2019-04-26

Countries

• Ireland

Study Locations