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Predicting Placental Pathologies by Ultrasound Imaging

NCT04506970 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2024-10-10

Study results available
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Summary

Intrauterine growth restriction (IUGR) is caused when the placenta cannot provide enough nutrients to allow normal growth of the fetus during pregnancy. It is unclear why IUGR happens, but an increase in inflammatory T cells in the placenta known as villitis of unknown etiology (VUE) is observed in many IUGR infants. The investigators aim to develop ultrasound methods for diagnosing VUE to understand it's role in IUGR.

Conditions

  • Intrauterine Growth Restriction
  • Villitis
  • IUGR

Interventions

DIAGNOSTIC_TEST

Comprehensive Doppler Ultrasound of the Placenta

Ultrasound measures to be collected include uterine artery (UtA) and umbilical artery (UA), systolic/diastolic (S/D) ratio, resistance index (RI), pulsatility index (PI) and presence of early diastolic notch.

OTHER

Verasonics Ultrasound scanner (ultra-sensitive Doppler imaging)

In addition, a Verasonics ultrasound scanner will be used for ultra-sensitive Doppler imaging. Data will be collected on vessel density, periphery-to-center vessel density ratio (VDR) and microvessel morphology.

Sponsors & Collaborators

Principal Investigators

  • Mauro Schenone, MD · Mayo Clinic

  • Elizabeth Ann L Enninga, PhD · Mayo Clinic

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-09-27
Primary Completion
2023-07-31
Completion
2023-10-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04506970 on ClinicalTrials.gov