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Lung Health and the Microbiome Among Adults in Botswana: the Go-hema Cohort

NCT07699614 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 900

Last updated 2026-07-13

No results posted yet for this study

Summary

Chronic respiratory diseases like chronic obstructive pulmonary disease (COPD) are responsible for millions of deaths each year, the majority of which occur in low- and middle-income countries (LMICs). LMICs also have high rates of abnormal lung function, including restrictive spirometric pattern (RSP), which can precede the development of chronic respiratory diseases and is associated with all-cause mortality. Additionally, LMICs in sub-Saharan Africa are home to the majority of the world's population of people with HIV (PWH). HIV increases the risk of COPD and COPD associated mortality, but the mechanisms underlying this risk are incompletely understood.

Conditions

  • Obstructive Pulmonary Disease
  • Restrictive Pulmonary Disease

Sponsors & Collaborators

Principal Investigators

  • Robert Gross, Medical · University of Pennsylvania

Eligibility

Min Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-12-01
Primary Completion
2029-12-20
Completion
2030-12-20

Countries

  • Botswana

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07699614 on ClinicalTrials.gov