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Multimodal Evaluation-Guided Surveillance-Intervention With Endoscopic Selective Neck Dissection for Post-Radiotherapy N3 Nasopharyngeal Carcinoma

NCT07692906 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2026-07-09

No results posted yet for this study

Summary

This randomized trial evaluates a multimodal surveillance strategy in nasopharyngeal carcinoma patients with high-risk N3 cervical lymph node involvement after radiotherapy. Patients are assigned to standard follow-up or an enhanced strategy using CEUS, imaging, and EBV DNA for risk assessment. The intervention group uses multimodal evaluation to identify high-risk patients who may undergo multidisciplinary review and selective neck dissection when indicated. The primary endpoint is failure-free survival (FFS). Secondary endpoints include OS, LRRFS, DMFS, and safety .

Conditions

  • Nasopharyngeal Cancinoma (NPC)

Interventions

PROCEDURE

Multimodal Evaluation-Guided Surveillance Strategy

Participants underwent multimodal follow-up evaluation after radiotherapy. Endoscopic selective neck dissection was performed only in participants with suspicious residual cervical lymph nodes identified by multimodal evaluation and with surgical indications.

Sponsors & Collaborators

  • West China Hospital of Stomatology

    collaborator UNKNOWN

  • Sichuan Cancer Hospital and Research Institute

    collaborator OTHER

  • General Hospital of Western Theater Command, PLA

    collaborator UNKNOWN

  • Yibin Second People's Hospital

    collaborator UNKNOWN

  • Miyi County People's Hospital

    collaborator UNKNOWN

  • Jintang First People's Hospital

    collaborator UNKNOWN

  • Yilong County people's Hospital

    collaborator UNKNOWN

  • Xuelei Ma MD

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-08-01
Primary Completion
2035-06-30
Completion
2035-06-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07692906 on ClinicalTrials.gov