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Xerostomia-optimised IMRT Versus Standard IMRT in NPC

NCT06282497 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 524

Last updated 2024-05-01

No results posted yet for this study

Summary

This is a multi-center, non-inferiority, open-label, randomized controlled phase III clinical trial in primary diagnosed nasopharyngeal carcinoma (NPC) patients without distant metastasis. This study aims to compare the regional control, survival outcomes, radiation-related toxicities, and quality of life (QoL) of xerostomia-optimized intensity-modulated radiotherapy versus standard intensity-modulated radiotherapy in NPC patients

Conditions

  • Nasopharyngeal Carcinoma ,Xerostomia,Radiotherapy

Interventions

RADIATION

Optimised neck CTV

neck CTV delineation extends from the lateral process of C1

RADIATION

standard neck CTV

neck CTV delineation extends from skull base

Sponsors & Collaborators

  • Zhongshan People's Hospital, Guangdong, China

    lead OTHER

Principal Investigators

  • Gui-qiong Xu, MD · Zhongshan People's Hospital, Guangdong, China

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-10-23
Primary Completion
2026-10-23
Completion
2029-10-23

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06282497 on ClinicalTrials.gov