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Surgery Plus Reduced Target Chemoradiotherapy vs Surgery Plus Reduced Dose Chemoradiotherapy for Newly Diagnosed Operable Nasopharyngeal Carcinoma.

NCT06529562 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 384

Last updated 2024-07-31

No results posted yet for this study

Summary

The goal of this clinical trial is to compare surgery plus reduced target chemoradiotherapy with surgery plus reduced dose chemoradiotherapy in newly diagnosed operable Nasopharyngeal Carcinoma.The main questions it aims to answer are:whether endoscopic surgery combined with reduced dose chemoradiotherapy vs surgery plus target reduction chemoradiotherapy can bring substantial survival benefits, lower toxicity, and shorter treatment cycle for patients with operable nasopharyngeal carcinoma .

Conditions

  • Nasopharyngeal Carcinoma

Interventions

RADIATION

Surgery combined with Target-reduction intensity-modulated radiotherapy

in control arm

RADIATION

Surgery combined with Dose-reduction intensity-modulated radiotherapy

in experimental arm

Sponsors & Collaborators

  • Fifth Affiliated Hospital, Sun Yat-Sen University

    collaborator OTHER

  • Sun Yat-sen University

    collaborator OTHER

  • Fifth Affiliated Hospital of Guangzhou Medical University

    collaborator OTHER

  • Huazhong University of Science and Technology Union Hospital (Nanshan Hospital)

    collaborator UNKNOWN

  • The First Affiliated Hospital of University of South China

    collaborator OTHER

  • People's Hospital of Guangxi Zhuang Autonomous Region

    collaborator OTHER

  • Nanchang City First Hospital

    collaborator UNKNOWN

  • Ming-Yuan Chen

    lead OTHER

Principal Investigators

  • Ming-Yuan Chen, MD,PhD · SUN yet-sen University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-11-01
Primary Completion
2032-11-01
Completion
2032-11-01

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06529562 on ClinicalTrials.gov