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Prophylactic Radiotherapy Optimization for Enhanced Thyroid Function Protection in NPC

NCT06752239 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 474

Last updated 2025-04-10

No results posted yet for this study

Summary

This study is a multicenter, non-inferiority, open-label, randomized controlled Phase III clinical trial. It aims to compare the efficacy of modified delineation radiotherapy (experimental group) versus standard delineation radiotherapy (control group) in the prophylactic irradiation of neck lymphatic drainage areas III/IVa in nasopharyngeal carcinoma. The study evaluates the incidence of primary hypothyroidism, quality of life, and adverse events between the two groups.

Conditions

  • Nasopharyngeal Carcinoma
  • Quality of Life
  • Thyroid Diseases
  • Radiotherapy Side Effect
  • Radiotherapy

Interventions

RADIATION

Modified delineation

Modified delineation (MD) of cervical lymphatic drainage areas, sparing the common carotid artery within the clinical target volume (CTV)

RADIATION

Standard delineation

Standard delineation

Sponsors & Collaborators

  • Jiangxi Provincial Cancer Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-01-01
Primary Completion
2030-12-31
Completion
2031-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06752239 on ClinicalTrials.gov