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Postoperative Cognitive Function After Different Anesthetic Techniques in Obese Patients

NCT07665645 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2026-06-24

No results posted yet for this study

Summary

Obese patients are at increased risk of postoperative cognitive dysfunction (POCD). The effects of different anesthetic techniques on postoperative cognitive function remain controversial. This prospective randomized study aimed to compare the effects of low-flow sevoflurane anesthesia, normal-flow sevoflurane anesthesia, and total intravenous anesthesia (TIVA) on postoperative cognitive function and recovery characteristics in obese patients undergoing elective laparoscopic abdominal surgery. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) before surgery, at postoperative 30 minutes, and on postoperative day 3.

Conditions

  • Obesity (BMI>30)
  • Postoperative Cognitive Function

Interventions

DRUG

Sevoflurane (Volatile Anesthetic)

Maintenance of general anesthesia with sevoflurane inhalation. Patients were assigned to either low-flow (1 L/min) or normal-flow (3 L/min) fresh gas flow anesthesia protocols.

DRUG

propofol

Maintenance of total intravenous anesthesia using continuous propofol infusion under BIS monitoring.

DRUG

Remifentanil

Continuous remifentanil infusion was administered during maintenance of anesthesia according to study protocol.

Sponsors & Collaborators

  • Gaziantep City Hospital

    lead OTHER

Principal Investigators

  • Ahmet Tunca, MD · Department of Anesthesiology and Reanimation, Gaziantep City Hospital

  • Seniyye Ü Zengin, MD · Department of Anesthesiology and Reanimation, Marmara University Faculty of Medicine, Pendik Training and Research Hospital

  • Meliha O Ergün, MD · Department of Anesthesiology and Reanimation, Marmara University Faculty of Medicine, Pendik Training and Research Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-01-10
Primary Completion
2023-06-20
Completion
2023-06-20

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07665645 on ClinicalTrials.gov