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Target-Controlled Infusion and Postoperative Neurocognitive Outcomes in Geriatric Patients

NCT07311447 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2025-12-31

No results posted yet for this study

Summary

This prospective observational study aims to evaluate the effects of target-controlled infusion (TCI) on postoperative neurocognitive function in geriatric patients undergoing major non-cardiac surgery. Elderly patients are at increased risk of postoperative cognitive dysfunction due to physiological changes and anesthesia-related factors. In this study, sedation management with TCI will be compared to manual infusion. Neurocognitive function will be assessed at multiple time points using the Mini-Mental State Examination (MMSE), and sedation levels will be monitored with the Bispectral Index (BIS) and the Richmond Agitation-Sedation Scale (RASS). The study aims to provide insights into safer sedation practices and improved cognitive outcomes in elderly surgical patients.

Conditions

  • Postoperative Cognitive Dysfunction (POCD)
  • Neurocognitive Function
  • Sedation and Analgesia
  • Geriatric Patients

Sponsors & Collaborators

  • Namigar Turgut

    lead OTHER

Principal Investigators

  • Namigar Turgut, MD · İstanbul Prof. Dr. Cemil Taşcıoğlu City Hospital

  • Zekeriya Ervatan, MD · İstanbul Prof. Dr. Cemil Taşcıoğlu City Hospital

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-05-05
Primary Completion
2025-10-31
Completion
2025-10-31

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07311447 on ClinicalTrials.gov