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Salivary Microbiota and Antimicrobial Resistance in Relation to Chlorhexidine Use

NCT07570927 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 11

Last updated 2026-05-06

No results posted yet for this study

Summary

This study evaluated the ecological effects of 0.06% chlorhexidine toothpaste on the salivary microbiota of healthy individuals, focusing on taxonomic composition, functional shifts, and prevalence of predicted antimicrobial resistance genes. Saliva samples were collected from eleven healthy participants at three specific time points: baseline (following a 4-week run-in period using a control toothpaste), intervention (after 12 weeks of using 0.06% chlorhexidine digluconate toothpaste), and washout (after a subsequent 12-week period using the control toothpaste). Sequencing targeted the 16S rRNA V3-V4 region.

Conditions

  • Antimicrobial Resistance (AMR)
  • Oral Microbiota
  • Oral Microbiome Health
  • Chlorhexidine
  • Saliva Microbiome

Interventions

DRUG

0.06% Chlorhexidine Digluconate Toothpaste

Participants used the toothpaste twice daily for 12 weeks.

Sponsors & Collaborators

  • Masaryk University

    lead OTHER

Study Design

Allocation
NA
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
25 Years
Max Age
44 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-04-11
Primary Completion
2022-11-29
Completion
2022-11-29

Countries

  • Czechia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07570927 on ClinicalTrials.gov