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Effects of Two Daily CHX Mouthrinses on Plaque, Gingivitis and Staining

NCT07351370 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 81

Last updated 2026-04-08

No results posted yet for this study

Summary

Τhe aim of this randomized clinical trial was to investigate the efficacy of two daily mouth rinses containing CHX and different combinations of H2O2 and CPC, when used adjunctive to mechanical oral hygiene, and compare them with a placebo mouth rinse. The primary outcomes evaluated were changes in i) bacterial biofilm accumulation, ii) gingival inflammation, and iii) tooth staining. Secondarily, patient's satisfaction and perspective after the use of these formulations was assessed.

Conditions

  • Mouthwashes
  • Chlorhexidine
  • Dental Plaque
  • Gingival and Periodontal Disease
  • Randomized Controlled Trial

Interventions

DRUG

chlorhexidine/ cetylpyridinium chloride/ hydrogen peroxide mouthwash

All participants were instructed to rinse for 3 months for 1 minute twice a day with 15 ml of the provided solution.

DRUG

Chlorhexidine/ cetylpyridinium chloride

All participants were instructed to rinse for 3 months for 1 minute twice a day with 15 ml of the provided solution

OTHER

Placebo

All participants were instructed to rinse for 3 months for 1 minute twice a day with 15 ml of the provided solution

Sponsors & Collaborators

  • Dental School

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-01-15
Primary Completion
2022-07-20
Completion
2022-07-20

Countries

  • Greece

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07351370 on ClinicalTrials.gov