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Effects of Mouthrinse on the Microbiome of the Oral Cavity and GI Tract

NCT05603650 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2025-12-17

No results posted yet for this study

Summary

The purpose of this research study is to identify the effects of 2 over-the-counter mouthwashes on bacteria and 3 viruses in the participant's mouth and gut. The participant will be randomly allocated to rinse their mouth twice daily either with Listerine mouthwash, Lumineux Oral Essentials mouthwash, or water. The overall duration of the study will be approximately 180 days and will include approximately 5 visits and 15-30 minutes for each visit with a total of approximately 2.5 hours of your time. Additionally, fecal matter will also be collected in some subjects using a commercial collection kit.

Conditions

  • Oral Bacterial Infection
  • Oral Infection
  • Microbial Colonization
  • Viral Infection

Interventions

OTHER

Lumineux Oral Essentials rinse

mouthrinse

OTHER

Listerine rinse

mouthrinse

Sponsors & Collaborators

  • University of California, Irvine

    lead OTHER

Principal Investigators

  • Petra Wilder-Smith, DDS, PhD · University of Calfornia Irvine

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-09-01
Primary Completion
2027-12-31
Completion
2027-12-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05603650 on ClinicalTrials.gov