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Correlation Between Capillary Refill Time and Perfusion Index in Critically Ill Patients

NCT07555041 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 250

Last updated 2026-05-01

No results posted yet for this study

Summary

Assessment of capillary refill time (CRT) is a cornerstone of tissue perfusion monitoring in critically ill patients.

CRT measurement is performed by applying brief and gentle pressure (for a few seconds) to a small area of skin until blanching occurs. CRT is defined as the time, in seconds, required for the skin surface to return to its initial color after release of pressure.

Although CRT is a monitoring tool used on a daily basis in emergency departments and critical care units, its practical measurement modalities remain poorly standardized and time-consuming. Consequently, there is no consensus regarding the most reproducible bedside method for CRT assessment. Moreover, repeated CRT measurements during patient management are resource-intensive in terms of medical time and may raise issues related to healthcare staff availability.

The perfusion index (PI) is a marker of tissue perfusion derived from a pulse oximetry sensor. This monitoring device is routinely used in all critically ill patients. It is placed on the finger and worn continuously, including during patient transport.

Because PI measurement is automatic and continuous, establishing its correlation with CRT could allow for more precise tissue perfusion monitoring while reducing the time burden associated with bedside assessments in critically ill patients.

Conditions

  • Shock State
  • Hemodynamics Instability
  • Microcirculation
  • Monitoring

Interventions

OTHER

Microcirculation monitoring

Microcirculation monitoring by Capillary Refill Time (CRT) measurements

OTHER

Microcirculation monitoring

Microcirculation monitoring by Perfusion Index (PI) measurements

Sponsors & Collaborators

  • Hospices Civils de Lyon

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-29
Primary Completion
2027-05-29
Completion
2027-05-29

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07555041 on ClinicalTrials.gov