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A Multimodal Prospective Cohort Study of Parkinsonism

NCT07553845 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 640

Last updated 2026-04-28

No results posted yet for this study

Summary

This is a single-center, prospective, observational cohort study designed to investigate the progression and differential diagnosis of Parkinsonism using a multimodal approach. The study plans to enroll 400 patients with Parkinsonism, 120 patients with rapid eye movement sleep behavior disorder, and 120 healthy controls, with follow-up for 5 years.

Assessments will include neuroimaging, clinical rating scales, biological samples, blood flow evaluation, neurophysiological testing, tremor analysis, and voice and video assessments. The study aims to characterize disease progression, explore factors associated with progression from rapid eye movement sleep behavior disorder to Parkinsonism, and improve the ability to distinguish among different Parkinsonian disorders.

Conditions

  • Parkinsonism
  • REM Sleep Behavior Disorder

Sponsors & Collaborators

  • Ruijin Hospital

    lead OTHER

Eligibility

Min Age
31 Years
Max Age
79 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-05-01
Primary Completion
2029-05-31
Completion
2029-05-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07553845 on ClinicalTrials.gov