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Imaging Studies of Cognitive Impairment in Parkinson s Disease

NCT01862744 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 76

Last updated 2019-12-12

No results posted yet for this study

Summary

Background:

\- Parkinson's disease causes slow movements, stiffness, and tremor. It can get worse over time, and in some cases can lead to dementia. Researchers are interested in how dementia affects the brain in people with Parkinson's disease. They will study both people with Parkinson s disease and healthy volunteers. They will give tests of thinking and memory, and look at brain activity using imaging studies. This may provide more information on what parts of the brain are not working well in people who have dementia related to Parkinson's disease.

Objectives:

\- To use imaging studies to see what parts of the brain do not work well in people with dementia caused by Parkinson's disease.

Eligibility:

* Individuals at least 40 years of age who have Parkinson s disease.
* Healthy volunteers at least 40 years of age.

Design:

* Participants will be screened with a medical history and physical exam.
* This study requires two outpatient visits over 2 days.
* Participants will have tests of thinking, memory, and concentration. They will answer questions and fill out questionnaires. The tests will also look at how quickly they can move and handle small objects. The tests will take about 3 hours.
* Participants will have magnetic resonance imaging to study the brain. Functional MRI (fMRI) can show what parts of the brain are used when performing a task. Participants will respond to images on a computer screen during fMRI.
* Treatment will not be provided as part of this study.

Conditions

Sponsors & Collaborators

  • National Institute of Neurological Disorders and Stroke (NINDS)

    lead NIH

Principal Investigators

  • Codrin I Lungu, M.D. · National Institute of Neurological Disorders and Stroke (NINDS)

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-04-04
Primary Completion
2015-01-30
Completion
2015-02-03

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01862744 on ClinicalTrials.gov