Evaluation of Pain Treatment After Total Knee Arthroplasty
NCT07538570 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 60
Last updated 2026-05-13
Summary
The purpose of the study is to characterize opioid use after total knee arthroplasty (TKA).
Conditions
Interventions
- DRUG
-
Placebo matched to SUZ for oral administration
- DRUG
-
Suzetrigine
Tablets for oral administration.
Sponsors & Collaborators
-
Vertex Pharmaceuticals Incorporated
lead INDUSTRY
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- QUADRUPLE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Max Age
- 80 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2026-04-24
- Primary Completion
- 2027-01-30
- Completion
- 2027-01-30
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Comparison of Opioid and Duloxetine for Postoperative Pain Control After Total Knee Arthroplasty: RCT
NCT04719585 ·Status: UNKNOWN ·Phase: NA
-
Local Infiltration Analgesia With and Without EXPAREL Following Total Knee Arthroplasty
NCT02713490 ·Status: COMPLETED ·Phase: PHASE4
-
Genicular Nerve Block for Total Knee Arthroplasty
NCT03706313 ·Status: COMPLETED ·Phase: PHASE4
-
Efficacy of Multimodal Perioperative Analgesia With Periarticular Drug Injection in Total Knee Arthroplasty(TKA)
NCT01042093 ·Status: COMPLETED ·Phase: NA
-
Improving Pain Management and Decreasing LOS After Total Hip Arthroplasty (THA) and Total Knee Arthroplasty (TKA)
NCT05307341 ·Status: UNKNOWN ·Phase: PHASE4
-
A Trial of SHR0410 Injection in Postsurgical Pain Management
NCT05394402 ·Status: TERMINATED ·Phase: PHASE2
-
Study to Examine Pain Relief With Supplemental Intrathecal Morphine in TKA Patients
NCT02620631 ·Status: UNKNOWN ·Phase: PHASE4
-
Peri-Articular-Multimodal Drug and Oral Celecoxib in Management of Postoperative Pain of Total Knee Arthroplasty
NCT05324995 ·Status: COMPLETED ·Phase: PHASE2
-
The Analgesic Effect of Nitroglycerin Patch for Postoperative Pain After Total Knee Replacement
NCT00375362 ·Status: UNKNOWN ·Phase: NA
-
Sufentanil Sublingual Tablet System for Postoperative Pain Management After Total Knee Arthroplasty
NCT04448457 ·Status: COMPLETED ·Phase: NA
-
Efficacy of Peripheral Nerve Blocks in Total Knee Arthroplasty
NCT07040709 ·Status: RECRUITING ·Phase: NA
-
Ultrasound-guided Adductor Canal Block for Total Knee Replacement
NCT02100579 ·Status: COMPLETED ·Phase: PHASE4
-
Management of Postoperative Pain After Total Knee Replacement.
NCT01163214 ·Status: COMPLETED ·Phase: PHASE4
-
Efficacy of NSAID and Acetaminophen in the Control of Post-Operative Pain in Patients Undergoing Total Knee Replacement
NCT05393414 ·Status: COMPLETED ·Phase: NA
-
Opioid-Sparing Protocol Comparing With Opioid-based Protocol After Bilateral Total Knee Arthroplasty
NCT04314505 ·Status: UNKNOWN ·Phase: PHASE4
-
Efficacy and Safety of IV Diclofenac (DIV075V)for Pain After Elective Orthopedic Surgery
NCT00507026 ·Status: COMPLETED ·Phase: PHASE3
-
Analgesia After Total Knee Arthroplasty
NCT00869037 ·Status: UNKNOWN ·Phase: PHASE4
-
Analgesic Efficacy of Pre-Operative Dose of Palmitoylethanolamide in Patients Undergoing Total Knee Arthroplasty
NCT07330765 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
Motor-Sparing Peripheral Nerve Blockade Facilitates Mobility Post Total Knee Arthroplasty: A Randomized Controlled Trial
NCT02773537 ·Status: COMPLETED ·Phase: NA
-
Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty
NCT02570503 ·Status: TERMINATED ·Phase: PHASE4
-
Post-op Ketamine Study
NCT03865550 ·Status: UNKNOWN ·Phase: NA
-
Effect of Bupivacaine Liposomes or Bupivacaine for Femoral Triangle or Adductor Block on Analgesia After Total Knee Replacement
NCT06653621 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4
-
Intraoperative Ketamine for Patients Undergoing Total Joint Arthroplasty
NCT04437888 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Adductor Canal Block in Total Knee Arthroplasty
NCT05715437 ·Status: UNKNOWN ·Phase: PHASE4
-
Comparing Pain Relief Between Exparel® Injection vs. On-Q Catheter as the Postsurgical Analgesia Following Total Knee Arthroplasty (TKA)
NCT02739230 ·Status: COMPLETED ·Phase: NA