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Comparison of Suzetrigine and Oxycodone for Postoperative Pain After Primary Total Knee Arthroplasty

NCT07219888 · Status: ENROLLING_BY_INVITATION · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 140

Last updated 2026-05-04

No results posted yet for this study

Summary

The purpose this study is determine whether postoperative oral dosage of suzetrigine is effective at controlling postoperative pain and reducing analgesic requirements following primary total knee arthroplasty (TKA) versus a control group of TKA patients receiving postoperative Oxycodone.

Conditions

  • Osteoarthritis (OA) of the Knee

Interventions

DRUG

oral suzetrigine

patient receives a two-week supply of oral suzetrigine upon discharge

DRUG

oral Oxycodone

Patient will receive a two-week supply of oral Oxycodone upon discharge

Sponsors & Collaborators

  • University of Louisville

    lead OTHER

Principal Investigators

  • Rodolfo Zamora, MD · University of Louisville

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
21 Years
Max Age
89 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-02-09
Primary Completion
2026-12-31
Completion
2027-04-30
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07219888 on ClinicalTrials.gov