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Intra-Venous Acetaminophen and Muscle Relaxants After Total Knee

NCT02449369 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 180

Last updated 2017-08-31

No results posted yet for this study

Summary

This is a prospective, three-arm, randomized, open-label trial to determine if a new pain control protocol which includes regular dosing of intravenous acetaminophen and orphenadrine for 48 hours after total knee surgery reduces the need for opioid pain medication and reduces average pain scores.

Conditions

  • Unilateral Knee Arthroplasty

Interventions

DRUG

Preop acetaminophen IV

DRUG

Preop orphenadrine IV

DRUG

Postop oral oxycodone & acetaminophen

DRUG

Postop hydromorphone IV

DRUG

Postop oral orphenadrine

DRUG

Postop oral oxycodone

DRUG

Postop acetaminophen IV

DRUG

Postop orphenadrine IV

Sponsors & Collaborators

  • Sagent Pharmaceuticals Inc.

    collaborator INDUSTRY

  • AdventHealth

    lead OTHER

Principal Investigators

  • thomas Looke, MD · AdventHealth

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-04-30
Primary Completion
2016-09-30
Completion
2016-09-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02449369 on ClinicalTrials.gov