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Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty

NCT02570503 · Status: TERMINATED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 64

Last updated 2022-03-04

Study results available
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Summary

This study will evaluate the use of a local injection around the knee (periarticular) during total knee replacement (TKR) surgery to see if it reduces postoperative pain levels. The injection is a combination of various medications which are thought to reduce pain levels.

Approximately 128 patients will participate in this study, half of the patients will receive this injection during surgery and the other half will receive a saline (salt water) injection. Pain scores after the surgery will be compared between the two groups.

All patients will also receive a long-acting (24 hours) morphine injection during surgery.

The hypothesis is that those participants receiving intrathecal Duramorph and local periarticular injections will have improved pain scores and reduced narcotic use when compared with intrathecal Duramorph alone at 48 hours postoperatively.

Conditions

  • Osteoarthritis, Knee

Interventions

DRUG

Ropivacaine

Ropivacaine (5mg/ml)-50ml

DRUG

Ketorolac

ketorolac (30mg/ml)- 1 ml

DRUG

Clonidine

clonidine (0.1mg/ml)- 0.8ml

DRUG

Epinephrine

epinephrine (1mg/ml)-1ml

DRUG

0.9% sodium chloride

Sodium chloride 0.9%- 47.7 ml

Sponsors & Collaborators

  • Virginia Commonwealth University

    lead OTHER

Principal Investigators

  • Gregory Golladay, MD · Virginia Commonwealth University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-10-31
Primary Completion
2021-02-11
Completion
2021-02-11

Countries

  • United States

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02570503 on ClinicalTrials.gov