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Perioperative Hyperoxia vs Normoxia Biomarker Trial

NCT07525661 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 76

Last updated 2026-04-13

No results posted yet for this study

Summary

This single-center randomized interventional study evaluated the biological effects of two perioperative oxygen strategies in adults undergoing elective laparoscopic lower abdominal surgery under standardized general anesthesia. Participants were assigned to receive either normoxia (FiO2 0.35) or hyperoxia (FiO2 0.80) after intubation and throughout the intraoperative period. The study assessed perioperative changes in circulating biomarkers related to pulmonary epithelial stress, endothelial glycocalyx injury, oxidative stress, and inflammation, together with blood gas and hemodynamic parameters. The study was completed before registration and is being registered retrospectively.

Conditions

  • Hyperoxia
  • Perioperative Care
  • Oxidative Stress
  • Endothelial Glycocalyx Injury

Interventions

OTHER

Perioperative Oxygen Strategy - Normoxia

Normoxia arm: FiO2 0.35 Intervention started immediately after intubation and maintained intraoperatively

OTHER

Perioperative Oxygen Strategy-Hyperoxia

Hyperoxia arm: FiO2 0.80 Intervention started immediately after intubation and maintained intraoperatively

Sponsors & Collaborators

  • Istanbul University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-07-01
Primary Completion
2019-01-01
Completion
2019-02-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07525661 on ClinicalTrials.gov