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Effects of Hyperoxia on Open Heart Surgery

NCT03012997 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2017-01-06

No results posted yet for this study

Summary

Patients undergoing Open Cardiac Surgery will be randomized into two groups. Group I will be ventilated with 40% Fio2 during induction, surgery and in Postoperative care unit. Group II will be ventilated with 100% Fio2 during induction and with 60-70% ( determined according to the arterial blood gas sample results) during surgery and in Postoperative care unit.

Hemodynamic parameters ( systolic arterial pressure, diastolic arterial pressure, heart rate ), Arterial blood gas samples ( PaO2, PaCO2, pH, Oxygen saturation, Lactate), and pre and post cardiopulmonary bypass Superoxide dismutase and malonyl aldehyde levels.

Conditions

  • Heart Valve Disease
  • Coronary (Artery) Disease

Interventions

OTHER

Fraction of inspired oxygen 40%

OTHER

Fraction of inspired oxygen 100%

Sponsors & Collaborators

  • Koşuyolu Kartal Heart Training and Research Hospital

    collaborator OTHER

  • Istanbul University

    lead OTHER

Principal Investigators

  • Guniz Koksal, Professor · Istanbul University

Study Design

Allocation
RANDOMIZED
Purpose
SCREENING
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-12-31
Primary Completion
2017-04-30
Completion
2017-04-30

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03012997 on ClinicalTrials.gov