MedTrace Logo

The Effect of Blood Carboxyhemoglobin Levels on Total Antioxidant (Tas), Total Oxidant(Tos), Hypoxia Inducible Factor-1a (hif1a) During Low-flow and Normal-flow Anesthesia

NCT05661045 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 130

Last updated 2024-06-17

No results posted yet for this study

Summary

In contrast to toxic CO concentrations, low-dose CO acts as a signaling molecule and can exert many complex cytoprotective effects. Therefore, the effects of low-dose CO are being investigated and developed as a new treatment method for use in various disease processes. However, these studies are mostly in vivo and in vitro studies and clinical studies have not reached a sufficient number. In this study, the effect of subclinical COHB levels on biomarkers such as TAS, TOS, HIF-1α will be evaluated.

Conditions

  • Carbon Monoxide Exposure

Interventions

PROCEDURE

low-flow anesthesia

Changes in blood carboxyhemoglobin levels as a result of exposure to rebreathing during low-flow anaesthesia.

Sponsors & Collaborators

  • Ataturk Training and Research Hospital

    lead OTHER

Principal Investigators

  • VEYSEL KOKSAL, PROF ASS · same

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-01-02
Primary Completion
2024-06-02
Completion
2024-06-02

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05661045 on ClinicalTrials.gov