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DMD Gene Variants and Cardiac Dysfunction in Young Males With Dystrophinopathies

NCT07515235 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 65

Last updated 2026-04-07

No results posted yet for this study

Summary

The goal of this observational study is to investigate whether the type, location, and extent of pathogenic variants in the DMD gene are associated with cardiac dysfunction in male children, adolescents, and young adults with dystrophinopathies. The study also evaluates whether cardiac biomarkers and electrocardiographic findings can facilitate the early identification of cardiac involvement. Participants will undergo electrocardiography, blood sampling for cardiac biomarker assessment, and transthoracic echocardiography, with cardiac dysfunction evaluated using ejection fraction (EF) and global longitudinal strain (GLS).

Conditions

  • Duchenne Muscular Dystrophy (DMD)
  • Becker Muscular Dystrophy
  • Cardiomyopathy

Sponsors & Collaborators

  • AHEPA University Hospital

    collaborator OTHER

  • Aristotle University Of Thessaloniki

    lead OTHER

Principal Investigators

  • Andreas Giannopoulos, Professor of Pediatrics and Pediatric Cardiology, MD, PhD · Aristotle University Of Thessaloniki

Eligibility

Min Age
2 Years
Max Age
24 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-26
Primary Completion
2028-01-31
Completion
2028-02-29

Countries

  • Greece

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07515235 on ClinicalTrials.gov