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Chronic Kidney Disease and Metabolic Disorders in the Elderly

NCT07494526 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 100000

Last updated 2026-03-27

No results posted yet for this study

Summary

The goal of this observational study is to investigate the impact of metabolic comorbidities on outcomes in elderly Chinese adults, through two parallel sub-cohorts: one comprising elderly individuals without chronic kidney disease (CKD) at baseline, and one comprising elderly patients with established CKD.

The main questions it aims to answer are:

Do metabolic diseases (diabetes, hypertension, hyperlipidemia, hyperuricemia, calcium-phosphorus disorders) increase the risk of incident CKD, major adverse cardiovascular events (MACE), and all-cause mortality in elderly individuals without CKD at baseline? What are the optimal diagnostic thresholds and criteria for CKD in the elderly population? How do metabolic comorbidities affect long-term outcomes - including all-cause mortality, end-stage renal disease (ESRD), and cardiovascular events - in elderly patients with established CKD? What is the comorbidity profile and disease burden of elderly CKD patients in China?

Participants in both sub-cohorts will:

Undergo baseline assessments including laboratory tests and clinical evaluations.

Provide longitudinal follow-up data through scheduled clinic visits and medical record linkage.

Contribute to a large-scale cohort of 100,000 elderly participants across multiple centers in China.

Conditions

Sponsors & Collaborators

  • Fudan University

    collaborator OTHER

  • Beijing Chao Yang Hospital

    collaborator OTHER

  • The First Affiliated Hospital of Dalian Medical University

    collaborator OTHER

  • Beijing Luhe Hospital

    collaborator OTHER

  • Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

    collaborator OTHER

  • Shandong Provincial Hospital

    collaborator OTHER_GOV

  • Second Xiangya Hospital of Central South University

    collaborator OTHER

  • Tianjin Medical University Chu Hsien-I Memorial Hospital

    collaborator UNKNOWN

  • Chinese PLA General Hospital

    lead OTHER

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-04-30
Primary Completion
2028-12-31
Completion
2028-12-31

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07494526 on ClinicalTrials.gov