CAPTURE-HFpEF: National Study of Identification and Phenotyping of Heart Failure With Preserved Ejection Fraction

Summary

The goal of this observational study is to improve early detection, characterization, and understanding of heart failure with preserved ejection fraction (HFpEF) in adults at risk of or diagnosed with HFpEF, including men and women across Danish regions.

The main questions to answer are:

Can systematic cardiovascular screening and deep phenotyping improve early identification and classification of HFpEF?

Which clinical, imaging, biomarker, and metabolic characteristics define subtypes (phenotypes) of HFpEF and predict disease progression and outcomes?

Researchers will compare participants with HFpEF, participants at risk of HFpEF, and relevant control groups to see if differences in biomarkers, imaging findings, and clinical characteristics can identify early disease stages and distinct HFpEF phenotypes.

Participants identified with HFpEF will:

* Undergo detailed cardiovascular examinations (e.g., echocardiography, CT and other imaging examinations, RHC, CPET)
* Provide blood and tissue samples for biomarker and metabolic analyses
* Complete clinical assessments and questionnaires
* Have relevant health data collected from national health registries
* Attend follow-up assessments to monitor disease progression

Conditions

• Heart Failure With Preserved Ejection Fraction (HFPEF)

Interventions

OTHER

HFpEF Observational Measurements

Observational measurements including collection of blood for biomarker and genetic analyses, echocardiography, ECG, and extraction of clinical data from electronic health records (comorbidities, medications, and prior hospitalizations). No treatment or procedure is assigned; all data reflect routine care and participant characteristics.

Sponsors & Collaborators

• Aalborg University Hospital

  collaborator OTHER

• Aarhus University Hospital

  collaborator OTHER

• Odense University Hospital

  collaborator OTHER

• Rigshospitalet, Denmark

  collaborator OTHER

• Zealand University Hospital

  collaborator OTHER

• Herlev and Gentofte Hospital

  lead OTHER

Principal Investigators

• Emil Wolsk, MD, PhD · Department of Cardiology, Herlev and Gentofte Hospital, Copenhagen, Denmark

Eligibility

Min Age

18 Years

Max Age

90 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-04-01

Primary Completion

2033-04-01

Completion

2035-04-01

Countries

• Denmark

Study Locations