PACIFIC-PRESERVED : PhenomApping, ClassIFication, and Innovation for Cardiac Dysfunction - HF With PRESERVED LVEF Study

Summary

This is a prospective multicenter study to decipher phenotypic variability within patients with heart failure and preserved left ventricular ejection fraction (HFpEF). From a registry of heart failure patients (2500 anticipated) hospitalized in the participating centers in the last 3 years, up to 300 participants (with a final ratio of 3 HFpEF patients, 2 patients with heart failure and reduced ejection fraction (HFrEF) and 1 matched subjects without heart failure will be enrolled for an extensive phenotyping with physical evaluation, biomarkers and omics, cardiac and vascular imaging and telemonitoring of cardiovascular parameters. Cluster analysis with machine learning methods will be performed to define phenogroups unique to the HFpEF patient population.

Conditions

• Heart Failure
• Heart Failure With Preserved Ejection Fraction

Interventions

OTHER

Extensive phenotyping

Prospective assessment of physical evaluation, biomarkers and omics, cardiac and vascular imaging and telemonitoring of cardiovascular parameters for 14 days.

Sponsors & Collaborators

• BPIfrance

  collaborator OTHER

• Sanofi

  collaborator INDUSTRY

• Institut de Recherches Internationales Servier

  collaborator OTHER

• Institut National de la Santé Et de la Recherche Médicale, France

  collaborator OTHER_GOV

• BioSerenity

  collaborator INDUSTRY

• Casis

  collaborator UNKNOWN

• Firalis SA

  collaborator INDUSTRY

• Fealinx

  collaborator UNKNOWN

• Centre National de la Recherche Scientifique, France

  collaborator OTHER

• ESPCI Paris

  collaborator OTHER

• University of Paris 5 - Rene Descartes

  collaborator OTHER

• Sorbonne University

  collaborator OTHER

• Assistance Publique - Hôpitaux de Paris

  lead OTHER

Principal Investigators

• Jean-Sébastien HULOT, MD PhD · AP - HP, Hôpital Européen Georges-Pompidou, Paris, France

Eligibility

Min Age

18 Years

Max Age

90 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-12-09

Primary Completion

2023-12-09

Completion

2025-12-31

Countries

• France

Study Locations