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Data-Driven Phenotyping in Heart Failure With Preserved Ejection Fraction

NCT07429396 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2026-02-24

No results posted yet for this study

Summary

The goal of this observational study is to learn how people with Heart Failure with Preserved Ejection Fraction (HFpEF) can be grouped into different "phenotypes" based on their clinical information. The researchers want to understand whether these groups have different health profiles and different responses during a cardiopulmonary exercise test (CPET).

The main questions this study aims to answer are:

* Can clinical data be used to identify meaningful HFpEF phenotypes?
* Do these phenotypes match well-known HFpEF scores, such as the H2FPEF and Heart Failure Association Pre-test Assessment, Echocardiography and Natriuretic Peptide (HFA-PEFF) scores?
* Do people in different phenotypes show different results on a CPET?

Participants will:

* Have their past clinical records reviewed if they were diagnosed with HFpEF at the Local Health Unit of the Leiria Region (ULS RL);
* A smaller group will attend one visit to complete a CPET, which measures how the heart, lungs and muscles respond during exercise.

This study includes adults aged 18 years or older who have HFpEF. The study does not involve any new treatments or experimental drugs.

Conditions

  • Heart Failure
  • Heart Failure, Diastolic
  • Heart Failure With Preserved Ejection Fraction (HFPEF)

Sponsors & Collaborators

  • Faculty of Medicine of Universidade de Lisboa (FMUL)

    collaborator UNKNOWN

  • Hospital Santo André - Centro Hospitalar de Leiria

    collaborator UNKNOWN

  • Fundação para a Ciência e a Tecnologia (FCT)

    collaborator UNKNOWN

  • Instituto Politécnico de Leiria

    lead OTHER

Principal Investigators

  • Rui M Fonseca-Pinto, PhD · ciTechCare - Center for Innovative Care and Health Technology, Polytechnic of Leiria

  • João C A Morais, PhD · ciTechCare - Center for Innovative Care and Health Technology, Polytechnic of Leiria

  • Vera L P Geraldes, PhD · Faculty of Medicine, University of Lisbon

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-12-01
Primary Completion
2027-08-01
Completion
2028-05-31

Countries

  • Portugal

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07429396 on ClinicalTrials.gov