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Conduction System Pacing vs. Biventricular Pacing for Cardiac Resynchronization Therapy

NCT07492979 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1100

Last updated 2026-03-25

No results posted yet for this study

Summary

The NORDIC-CSP trial is an investigator-initiated, blinded, nordic RCT aimed at evaluating whether using direct pacing of the HIS bundle (HIS)-pacing or left bundle branch (LBB) pacing is superior to conventional biventricular pacing in reducing the incidence of the composite endpoint of death and non-planned HF hospitalization. The study will be conducted in the 4 CRT-centres in Denmark and 6-8 centres from countries Sweden, Norway and Finland.

Conditions

  • Cardiac Resynchronisation Therapy (CRT)
  • Heart Failure
  • Conduction System Pacing

Interventions

PROCEDURE

HIS or LBBB -CRT

HIs pacing og LBB pacing at the implanteres discretion

PROCEDURE

Conventional BiV-CRT

An LV-lead in a side-branch of the coronary sinus

Sponsors & Collaborators

  • Rigshospitalet, Denmark

    lead OTHER

Principal Investigators

  • Niels Risum Risum, MD, PhD · Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

  • michael vinther, MD, PhD · Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

  • Berit Philbert · Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-03-01
Primary Completion
2031-03-01
Completion
2031-07-01

Countries

  • Denmark
  • Finland
  • Norway
  • Sweden

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07492979 on ClinicalTrials.gov