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A Pilot Study on Skeletal Muscle Proteome Dynamics in Younger and Older Men Undertaking Normal Activity or Resistance Exercise Training.

NCT07473297 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 8

Last updated 2026-03-16

No results posted yet for this study

Summary

The goal of this basic research study is to investigate effect of resistance exercise on the quality of muscle proteins in younger and older men. The main question\[s\] it aims to answer \[is/are\]: whether there is a difference in muscle protein quality between younger and older adults and if resistance exercise training has a beneficial impact on the quality of muscle proteins? Participants will perform five bouts of unilateral leg press exercise during a 14 day period of deuterium oxide consumption and biopsy samples will be taken from both their exercised leg and non-exercised leg before and after the intervention period to enable the measurement of muscle protein abundances and turnover rates.

Conditions

  • Ageing Well

Interventions

OTHER

Resistance Exercise

Unilateral leg press. Participants undertook a supervised training session of unilateral leg-press exercise at a standardized time of day. During each session, participants performed a warm-up consisting of 5 repetitions at 70 % of 10RM. Participants performed three sets of 10 repetitions at a lifting intensity of 90 % of 10 RM with 2- to 3-min rest between sets.

Sponsors & Collaborators

  • Biotechnology and Biological Sciences Research Council

    collaborator OTHER

  • Liverpool John Moores University

    lead OTHER

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
20 Years
Max Age
75 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-03-10
Primary Completion
2023-03-12
Completion
2025-08-28

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07473297 on ClinicalTrials.gov