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Pathophysiological Mechanisms of Activity-Related Dyspnea in Heart Failure: A Pilot Study

NCT02007486 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 32

Last updated 2017-02-14

No results posted yet for this study

Summary

Dyspnea (breathlessness) on exertion is the most prevalent and distressing symptom of heart failure (HF). Nevertheless, the mechanisms of dyspnea in HF remain poorly understood. Thus, the general aim of this pilot study is to advance our understanding of the mechanisms of activity-related dyspnea in patients with HF. Studies will be performed in patients with mild, moderate and severe HF (n=24) as well as in healthy, age- and sex-matched control subjects (n=8). We will test the hypothesis that the increased prevalence and severity of activity-related dyspnea in HF reflects the interaction between an exaggerated drive to breathe and the inability of the respiratory system to meet this increased demand. Detailed physiological and perceptual responses to bicycle exercise will be examined and compared, first, between HF patients and healthy control subjects and, second, across patients with varying degrees of HF severity. The results from this preliminary study will be used to help design future studies in this patient population.

Conditions

Interventions

OTHER

Cardiopulmonary Exercise Testing

Symptom-limited incremental exercise testing (10 watts/min) on an electronically braked cycle ergometer

Sponsors & Collaborators

Principal Investigators

  • Dennis Jensen, Ph.D. · McGill University

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-01-31
Primary Completion
2017-12-31
Completion
2017-12-31

Countries

  • Canada

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02007486 on ClinicalTrials.gov