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Monoaxial vs. Polyaxial Percutaneous Hybrid Stabilization

NCT07408726 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 44

Last updated 2026-04-09

No results posted yet for this study

Summary

Vertebral body fractures in older adults mostly affect the thoracolumbar junction and are challenging to treat due to osteoporosis and other comorbidities. Treatment options range from conservative approaches to minimally invasive procedures like vertebroplasty or balloon kyphoplasty, as well as surgical techniques such as posterior or combined stabilization. A common method for more severe fractures (from OF3 onwards) is percutaneous bisegmental hybrid stabilization using cement-augmented pedicle screws and balloon kyphoplasty. Polyaxial screws are easier to implant but offer less biomechanical stability. In contrast, monoaxial screws provide greater stiffness, allowing better correction of kyphosis and restoration of vertebral body height. The study compares radiological and clinical outcomes in patients aged 60 and older with thoracolumbar fractures (T11-L4) between monoaxial and polyaxial hybrid stabilization. The primary goal is to evaluate and compare the degree of kyphosis correction six months after surgery.

Conditions

  • Thoracolumbar
  • Fractures in the Elderly

Interventions

DEVICE

Monoaxial instrumentation - the M.U.S.T. Monoaxial Pedicle Screw Cannulated (Medacta International SA, Switzerland)

In this study, fractures between the 11th thoracic (T11) and 4th lumbar (L4) vertebra (both included) will be treated surgically using either monoaxial or polyaxial bisegmental hybrid stabilization. Hybrid stabilization consists of posterior cement-augmented pedicle screw instrumentation combined with balloon kyphoplasty of the fractured vertebral body. For bisegmental hybrid stabilization, standard cannulated and perforated pedicle screws, either monoaxial (M.U.S.T. Monoaxial Pedicle Screw Cannulated (Medacta International SA, Switzerland)) or polyaxial (M.U.S.T. LT Pedicle Screw System (Medacta International SA, Switzerland)), will be placed in the vertebrae adjacent to the fractured vertebral body.

DEVICE

Polyaxial instrumentation - the M.U.S.T. LT Pedicle Screw System (Medacta International SA, Switzerland)

In this study, fractures between the 11th thoracic (T11) and 4th lumbar (L4) vertebra (both included) will be treated surgically using either monoaxial or polyaxial bisegmental hybrid stabilization. Hybrid stabilization consists of posterior cement-augmented pedicle screw instrumentation combined with balloon kyphoplasty of the fractured vertebral body. For bisegmental hybrid stabilization, standard cannulated and perforated pedicle screws, either monoaxial (M.U.S.T. Monoaxial Pedicle Screw Cannulated (Medacta International SA, Switzerland)) or polyaxial (M.U.S.T. LT Pedicle Screw System (Medacta International SA, Switzerland)), will be placed in the vertebrae adjacent to the fractured vertebral body.

Sponsors & Collaborators

  • Medical University Innsbruck

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-05-01
Primary Completion
2028-09-01
Completion
2028-11-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07408726 on ClinicalTrials.gov