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Digital Angiography-Derived Fractional Flow Assessment for Intracranial Stenosis

NCT07309705 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 400

Last updated 2025-12-30

No results posted yet for this study

Summary

The goal of this observational study is to learn whether a digital angiography derived fractional flow reserve (DPR) measurement can improve the prediction of stroke risk in adults with symptomatic intracranial atherosclerotic stenosis, defined as 50 to 99 percent narrowing.

The main questions it aims to answer are:

Does DPR identify patients who are at higher risk of recurrent stroke despite receiving standard medical treatment? Is DPR more accurate than traditional angiographic stenosis measurements for assessing the functional severity of intracranial arterial disease?

Participants will undergo routine digital subtraction angiography as part of their clinical evaluation. Their angiographic images will be analyzed using a computational method to estimate blood flow impairment, and they will be followed for up to 12 months to monitor stroke related outcomes.

Conditions

  • Intracranial Atherosclerosis ICAS
  • Hemodynamic
  • Stroke

Interventions

DRUG

Standardized medical therapy targeting vascular risk factors and stroke prevention

Dual antiplatelet treatment and management of vascular risk factors, in accordance with AHA/ASA guidelines

Sponsors & Collaborators

  • Suining Hospital of Traditional Chinese Medicine

    collaborator UNKNOWN

  • Nanfang Hospital, Southern Medical University

    collaborator OTHER

  • The First Affiliated Hospital of Zhengzhou University

    collaborator OTHER

  • Xuanwu Jinan Hospital

    collaborator UNKNOWN

  • The First Affiliated Hospital of University of Science and Technology of China

    collaborator OTHER

  • First Affiliated Hospital of Chongqing Medical University

    collaborator OTHER

  • Jiangmen Central Hospital

    collaborator OTHER

  • Hebi People's Hospital

    collaborator UNKNOWN

  • Shanghai Sixth People's Hospital Anhui Branch

    collaborator UNKNOWN

  • Xuanwu Hospital, Beijing

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-01
Primary Completion
2027-01-01
Completion
2028-01-01

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07309705 on ClinicalTrials.gov