Cerebral Autoregulation in Patients With Symptomatic Cerebral Atherosclerotic Stenosis

Summary

In this multi-center prospective observational study within a cohort of symptomatic cerebral atherosclerotic stenosis (sCAS) patients, 850 subjects were planed to be enrolled to explore the relationship between cerebral autoregulation (CA) and stroke recurrence, determine the threshold values of CA parameter for predicting stroke recurrence associated with particular stenosis.

Conditions

• Cerebrovascular Stroke
• Cerebral Artery Stenosis

Interventions

DIAGNOSTIC_TEST

Cerebral autoregulation assessment

Cerebral autoregulation assessment will be conducted by specialized neurovascular ultrasound doctors during 0-3 and 10-30 days after stroke onset.The recorded data will be stored for further cerebral autoregulation analysis.

Sponsors & Collaborators

• Shenzhen Second People's Hospital

  collaborator OTHER

• Shanghai Jiao Tong University Affiliated Sixth People's Hospital

  collaborator OTHER

• The First Affiliated Hospital with Nanjing Medical University

  collaborator OTHER

• The First Affiliated Hospital of University of South China

  collaborator OTHER

• Eighth Affiliated Hospital, Sun Yat-sen University

  collaborator OTHER

• The First Affiliated Hospital of Hebei North University

  collaborator OTHER

• Qilu Hospital of Shandong University

  collaborator OTHER

• The Affiliated Hospital of Qingdao University

  collaborator OTHER

• The Affiliated Hospital of Yanbian University

  collaborator OTHER

• Yi Yang

  lead OTHER

Principal Investigators

• Yi Yang, MD, PhD · Neuroscience Center, Department of Neurology, The First Hospital of Jilin University

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-01-14

Primary Completion

2025-12-24

Completion

2026-08-30

Countries

• China

Study Locations