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Arterial Wall Shear Stress After Intracranial Artery Recanalization

NCT06290271 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 160

Last updated 2024-03-04

No results posted yet for this study

Summary

There has been consistent research on the cerebral blood flow features in ischemic stroke patients with acute occlusion of major intracranial arteries. However, studies analyzing the overall features of the major intracranial artery blood flow in the periods of pre and post-recanalization are still lacking. Time-of-flight magnetic resonance angiography (TOF-MRA) is extensively utilized to evaluate the intracranial arteries. The arterial signal intensity from MRA-TOF varies across subjects and arterial subtypes, leading to the development of the Signal Intensity Gradient (SIG) concept. SIG has demonstrated a strong correlation with Computational Fluid Dynamics (CFD), a known method for reflecting wall shear stress. SIG could be associated with the pathophysiology of wall shear stress. We aim to investigate the blood flow patterns and characteristics in the periods of pre and post-recanalization using SIG.

Conditions

  • Intracranial Artery Occlusion

Interventions

OTHER

Intracranial artery flow pattern

the cerebral blood flow patterns observed after the occluded artery has been recanalized.

Sponsors & Collaborators

  • Seoul National University Hospital

    collaborator OTHER

  • Chungnam National University Hospital

    collaborator OTHER

  • Asan Medical Center

    collaborator OTHER

  • Chonnam National University Hospital

    collaborator OTHER

  • Korea University Ansan Hospital

    collaborator OTHER

  • SMG-SNU Boramae Medical Center

    collaborator OTHER

  • Chonbuk National University Hospital

    lead OTHER

Principal Investigators

  • Keun-Hwa Jung, Prof. · Seoul National University Hospital

  • Hee Jung Song, Prof. · Chungnam National University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-08-01
Primary Completion
2024-06-30
Completion
2024-12-31

Countries

  • South Korea

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06290271 on ClinicalTrials.gov