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Blood Sampling Pre- and Post-Propofol Administration to Characterize the Blood Proteome Using Different Research Assays

NCT07295795 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 10

Last updated 2026-04-21

No results posted yet for this study

Summary

Background:

Propofol is a drug that helps people fall asleep quickly and stay asleep during surgery, so they do not feel any pain. This drug is also used to sedate critically ill people who must be on a ventilator (a machine to help them breathe). To better understand how to interpret blood tests in these ill people, researchers need to know more about how the drug itself may change proteins in the blood.

Objective:

To collect blood samples from people before and after propofol is administered for surgery.

Eligibility:

People aged 18 years or older who are scheduled for surgery that requires sedation with propofol.

Design:

Participants will have data collected. This data will include age, sex, and ethnicity. They will be asked about their medical history.

Participants will have blood samples collected before and after they receive propofol for their surgery. The blood will be collected from lines already installed for the surgery; no new needlesticks will be done for the study. A total of 3 teaspoons of blood will be drawn.

The samples will be compared to each other to look for any changes caused by the drug.

No follow-up visits are required.

Conditions

  • Critically Ill Surgical Patients

Sponsors & Collaborators

  • National Institutes of Health Clinical Center (CC)

    lead NIH

Principal Investigators

  • Andrew J Mannes, M.D. · National Institutes of Health Clinical Center (CC)

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-02-10
Primary Completion
2026-02-13
Completion
2026-02-13

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07295795 on ClinicalTrials.gov