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Antimicrobial and Anti-inflammatory Effects of Simvastatin as an Intracanal Medication

NCT07256561 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 54

Last updated 2025-12-01

No results posted yet for this study

Summary

Successful endodontic treatment and a predictable outcome can only be achieved by effective root canal debridement, irrigation, and elimination of microorganisms .

The outcome of endodontic treatment performed in controlled clinical environment has demonstrated success rate around 90%.

In certain cases, endodontic treatment may fail, one of the most common reasons is inability to eliminate microorganisms from the root canal. When non-surgical root canal therapy fails, the treatment options include orthograde re-treatment, periradicular surgery, or extraction.

Simvastatin (SIM) is a drug used primarily to treat hyperlipidemia and protect against cardiovascular diseases. It has been shown to possess pleiotropic effects such as antimicrobial, anti-inflammatory, immunomodulatory, antioxidant, and bone-forming properties .

The side chain of this material has a single methyl group. It inhibits hydroxymethyl glutarylcoenzyme reductase that prevents endogenous cholesterol synthesis

Conditions

  • Endodontically Retard Teeth
  • Periapical Radiolucency

Interventions

PROCEDURE

Simvastatin as an intracanal medication

to evaluate the antimicrobial and anti-inflammatory effects of Simvastatin as an intracanal medication in endodontic retreatment of single rooted teeth with periapical radiolucency.

Sponsors & Collaborators

  • Hadeer Maher Mostafa Mohamed

    lead OTHER_GOV

Principal Investigators

  • Mervat Ibrahim Fawzy, Professor · Faculty of Dental Medicine for Girls Al Azhar University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-08-10
Primary Completion
2026-08-01
Completion
2026-08-10

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07256561 on ClinicalTrials.gov