MedTrace Logo

Evaluation of Different Medicaments in the Management of Necrotic Primary Molars by Lesion Sterilization and Tissue Repair

NCT06926322 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 108

Last updated 2025-10-02

No results posted yet for this study

Summary

Management of non-vital primary molars is challenging due to the natural anatomy of primary teeth, patients' young age, and their behavior toward dental treatment. A simple and effective technique such as Lesion Sterilization and Tissue Repair offers a solution to cases with poor prognosis; however, the medicaments used in this technique have some limitations. This study will evaluate three different medicaments regarding the clinical success, radiographic success, and antibacterial activity.

Conditions

  • Pain, Postoperative
  • Root Resorption
  • Persistent Infection
  • Necrotic Pulp

Interventions

DRUG

Conventional double antibiotic paste of Metronidazole 500 mg plus Ciprofloxacin 500 mg mixed with propylene glycol

The studied medicament will be placed onto the floor of the pulp chamber.

DRUG

Double antibiotic paste of Metronidazole and Ciprofloxacin loaded chitosan-coated silver nanoparticles

The studied medicament will be placed onto the floor of the pulp chamber.

DRUG

chitosan-coated silver nanoparticles

The studied medicament will be placed onto the floor of the pulp chamber.

Sponsors & Collaborators

  • Ain Shams University

    lead OTHER

Principal Investigators

  • Nagwa Khattab · Ain Shams University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
4 Years
Max Age
8 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-10-31
Primary Completion
2027-08-31
Completion
2030-08-31

Countries

  • Egypt

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06926322 on ClinicalTrials.gov