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Antibacterial Effect of Nano Silver Fluoride vs Chlorhexidine on Occlusal Carious Molars Treated With Partial Caries Removal Technique

NCT03186261 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 44

Last updated 2021-09-16

Study results available
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Summary

* The teeth of the patients that meet inclusion criteria will be anesthetized, isolated with a rubber dam.
* Cavity opened using conventional high-speed rotary instruments.
* The central cariogenic biomass and the superficial parts of the necrotic dentine will be removed with round burs.
* Caries lesion will be completely removed in the enamel/dentin junction.
* The excavation procedure will be terminated as soon as the soft and wet dentine was removed and the remaining tissue was leathery but not hard on exploring.
* A dentinal sample will then be collected from the base of the cavity using sterile spoon excavator as a baseline for bacteriological assessment.
* Then, application of either intervention or control agent, another dentinal sample will be collected using a sterile excavator and transferred into sterile tubes and transferred to the laboratory for microbiological analysis.
* Filling of the cavity with resin composite restoration.
* All clinical procedures will be carried out at the same visit.

Conditions

  • Dental Caries

Interventions

DRUG

Nano silver fluoride solution

Nano silver fluoride that composed of silver nanoparticles, chitosan and fluoride that combines preventive and antimicrobial properties.

DRUG

Cavity Cleanser

Moistens dentin surface after cavity preparation using a micro brush.

Sponsors & Collaborators

  • Cairo University

    lead OTHER

Principal Investigators

  • Randa Hafez, PHD · Cairo University

  • Mai Mamdouh, PHD · Cairo University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-04-01
Primary Completion
2018-11-01
Completion
2018-12-28
FDA Drug
Yes

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03186261 on ClinicalTrials.gov