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Omics Sciences for the Identification of Pathogenetic Mechanisms and Biomarkers in Neurodegenerative Diseases

NCT07235111 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1200

Last updated 2025-11-25

No results posted yet for this study

Summary

The study aims to use 'omics' sciences, employing the most advanced technologies currently available, in order to identify pathogenic genomic variants, proteins and/or altered molecular pathways in neurodegenerative diseases and to obtain a new and more complete characterisation of subjects affected by the neurodegenerative diseases under study. Thanks to the integration of genomic, gene expression (transcriptomic and epigenomic), protein and metabolic data and clinical data, the study also aims to identify new markers for the diagnosis, prognosis, also in terms of response to therapy, and monitoring of neurodegenerative diseases.

The study involves the enrolment of at least 1.200 individuals with neurodegenerative disease.

Conditions

  • Alzheimer Disease
  • FTD
  • Young-onset Dementia
  • MCI
  • Parkinson Disease
  • ALS (Amyotrophic Lateral Sclerosis)

Sponsors & Collaborators

  • Istituto Italiano di Tecnologia

    collaborator OTHER

  • Ospedale Policlinico San Martino

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-02-28
Primary Completion
2034-09-17
Completion
2039-09-17

Countries

  • Italy

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07235111 on ClinicalTrials.gov